Cushing Syndrome Causes and Symptoms

Cushing Syndrome

Cushing syndrome is a rare endocrine confusion that is caused mainly because of the hormonal disproportion in the body. It is also known as hypercriticism or hyper adrenocorticism. Usually, it affects person between the age range of 20 and 50. As per judgment, 10 to 15 of every million people are affected each year with this problem and the impact is quite sever.. Cushing syndrome is named after American doctor Dr. Harvey Cushing. It is caused when the body’s tissues are uncovered to excessive levels of cortisol for huge period of time. Individuals or patients who suffer from type 2 diabetes, obesity and high blood pressure have high risks of developing this problem.

Causes of Cushing syndrome:

Experts believe there are no particular reason for such problems however there are affective solution to treat the problem and some causes that can result in the problem are mentioned below:

  •   Most cases of Cushing syndrome are caused by pituitary adenomas. The benign, or non-cancerous, tumors of the pituitary gland secrete excess amounts of ACTH. Women are five times more sensitive for such problems.
  •   An abnormal behavior of the adrenal glands can also be responsible for the Cushing syndrome. Mostly the problem start at the age of 40and then it continues.
  •   In some cases the problem is inherited and the tendency to develop tumors of one or more endocrine glands.

Signs and symptoms of Cushing syndrome:

  •   Severe fatigue and this are some common problems at the initial stages.
  •   Muscle weakness and even joint pains.
  •   The overall shape of the face changes and generally becomes round in shape.
  •   Facial flushing is also seen among the patients.
  •   Acne and other pimples start developing over the complete face.
  •   Decreased libido is also seen among the patients at early stages.
  •   Headache and at times the intensity are mild but can fluctuate.
  •   Erectile dysfunction is seen in males
  •   Tremendous weight gain and around the upper portion of the body.
  •   The skin quality also changes and it is more prone to bruises and cuts.
  •   There are problems of high blood pressure
  •   Glucose intolerance can lead to diabetes among some patients.
  •   The healing power reduces to cuts or bite from some insects.
  •   Depression, anxiety and irritability are quite regular.
  •   Increase in the frequency of urine.
  •   The patient may get irritated and this are nothing because f the problem or Cushing syndrome.
  •   More visible of the body and facial hair
  •   Irregular or absent menstrual periods in females
  •   Bone loss that leads to fractures over time

Diagnosis of Cushing’s syndrome:

There are several tests that are performed to diagnose Cushing syndrome in patient. Such tests include:


  •   LDDS Test (Low Dose Dexamethasone Suppression Test
  •   Urine Test
  •   Dexamethasone-CRH Test
  •   Midnight Plasma Cortisol and Late-night Salivary Cortisol Measurements:
  •   Petrosal Sinus Sampling
  •   CRH Stimulation Test
  •   Radiologic Imaging for visualization of endoctrine glands
  •   HDDS or High Dose Dexamethasone Suppression Test

Treatment for Cushing syndrome:

The treatments are used to minimize the effect and some common treatments include:

  • Corticosteroid use: high dose of this chemical is applied and this helps the problem to reduce a bit or even helpful in curing as well.
  •  Surgery: in some cases surgery is conducted and this is helpful.
  • Radiotherapy (radiation therapy): in case the tumor can’t be reduced and this therapy is used which can help the cause.
  •  Drugs: several drugs are available to treat the problem and this can be helpful enough.
  • Chemotherapy: At some stage chemotherapy can also be helpful enough.

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